Blood oxidative stress markers and Plasmodium falciparum malaria in non‐immune African children

• DOI: 10.1111/bjh.12636
• Publication Date: 2014-01-15T06:55:24Z
• Authors: Ruth Aguilar; Tiziana Marrocco; Oleksii A. Skorokhod; Arnoldo Barbosa; Augusto Nhabomba; Maria N. Manaca; Caterina Guinovart; Llorenç Quintó; Paolo Arese; Pedro L. Alonso; Carlota Dobaño; Evelin Schwarzer
• Keywords: Convalescence; Pathogenesis

Summary Converging in vitro evidence and clinical data indicate that oxidative stress may play important roles P lasmodium falciparum malaria, notably the pathogenesis of severe anaemia. However, modifications red blood cell ( RBC )‐membrane by 4‐hydroxynonenal (4‐ HNE ) haemoglobin‐binding, previously hypothesized to contribute mechanistically have not yet been tested for significance. In 349 non‐immune M ozambican newborns recruited a double‐blind placebo‐controlled chemoprophylaxis trial, markers including 4‐ ‐conjugates membrane‐bound haemoglobin were longitudinally assessed from 2·5 24 months age, at first acute malaria episode convalescence. During shown increase significantly parasitized non‐parasitized s. parallel, advanced oxidation protein products AOPP rose plasma. correlated with established plasma but markers. High individual levels predictive increased incidence rates children until 2 years life elevated convalescence accompanied sustained anaemia after episode, indicating as novel patho‐mechanistic factor malaria. A second marker, binding ‐membranes, induce clearing s circulation, was lower rates. Further studies will show whether or higher membrane‐haemoglobin values provide protection against