Long non‐coding RNA MALAT1 is an inducible stress response gene associated with extramedullary spread and poor prognosis of multiple myeloma

• DOI: 10.1111/bjh.14882
• Publication Date: 2017-08-03T03:22:44Z
• Authors: Hiroshi Handa; Yuko Kuroda; Kei Kimura; Yuta Masuda; Hikaru Hattori; Lobna Alkebsi; Morio Matsumoto; Tetsuhiro Kasamatsu; Nobuhiko Kobayashi; Ken‐ichi Tahara; Makiko Takizawa; Hiromi Koiso; Takuma Ishizaki; Hiroaki Shimizu; Akihiko Yokohama; Norifumi Tsukamoto; Takayuki Saito; Hirokazu Murakami
• Keywords: Pathogenesis

Summary Extramedullary myeloma ( EMM ) occurs when develops outside the bone marrow; it often after chemotherapy and is associated with acquisition of chemo‐resistance a fatal course. The mechanisms underlying extramedullary spread have not yet been fully elucidated. MALAT 1 highly abundantly ubiquitously expressed long non‐coding RNA that plays important roles in cancer metastasis. aims this study were to clarify association elucidate mechanism formation under chemotherapeutic pressure. expression was significantly higher multiple MM than monoclonal gammopathy undetermined significance. Furthermore, markedly compared corresponding intramedullary cells. A level shorter overall progression‐free survival. positively correlated HSP 90 AA 1, AB 90B1 but TP 53 expression. upregulated by bortezomib doxorubicin. Considering known functions , our results suggest acts as stress response gene chemotherapy, thereby linking formation. Elucidating biological implication contributes deeper understanding concerning pathogenesis investigation novel therapeutic targets for .