Inflammatory profile of lower risk myelodysplastic syndromes

• DOI: 10.1111/bjh.19530
• Publication Date: 2024-05-22T02:54:20Z
• Authors: Joanne Topping; Adele Taylor; Fatima Nadat; Simon Crouch; Alice Ibbotson; Jaroslav Čermák; Argiris Symeonidis; Aurelia Tatic; Saskia Langemeijer; Eva Hellström‐Lin...; Dominic Culligan; Hege Gravdahl Gar...; John Ashcroft; Emma Nga; Jane Parker; Seye Kolade; Michael F. McDermott; Theo De Witte; David Bowen; Alexandra Smith; Catherine Cargo; Sinisa Savic
• Keywords: Pathogenesis

Summary The precise link between inflammation and pathogenesis of myelodysplastic syndrome (MDS) is yet to be fully established. We developed a novel method measure ASC/NLRP3 protein specks which are specific for the NLRP3 inflammasome only. combined this with cytokine profiling characterise various inflammatory markers in large cohort patients lower risk MDS comparison healthy controls defined autoinflammatory disorders (AIDs). were significantly elevated compared ( p < 0.001) these levels comparable those found AIDs. distribution positive only ASC was different ones suggesting that other ASC‐containing complexes might important MDS. Patients MDS‐SLD had lowest interleukin (IL)‐1β, tumour necrosis factor (TNF), IL‐23, IL‐33, interferon (IFN) γ IFN‐α2, diagnostic categories. also TNF positively associated progression more aggressive form disease IL‐6 IL‐1β time first red blood cell transfusion. Our study shows there value analysing biomarkers MDS, but their prognostic utility validated.