Gleason score 5 + 3 = 8 prostate cancer: much more like Gleason score 9?

• DOI: 10.1111/bju.13239
• Publication Date: 2015-07-24T15:07:06Z
• Authors: Brandon A. Mahal; Vinayak Muralidhar; Yu‐Wei Chen; Toni K. Choueiri; Karen E. Hoffman; Jim C. Hu; Christopher J. Sw...; James B. Yu; Felix Y. Feng; Quoc‐Dien Trinh; Paul L. Nguyen
• Keywords: Male; 03 medical and health sciences; 0302 clinical medicine; Humans; Prostatic Neoplasms; Middle Aged; Neoplasm Grading; Prognosis; Risk Assessment; Aged; 3. Good health

To determine whether patients with Gleason score 5 + 3 = 8 prostate cancer have outcomes more similar to other disease or 9 disease.The Surveillance, Epidemiology and End Results (SEER) database was used study 40 533 men diagnosed N0M0 from 2004 2011. Using 4 as the referent, Fine Gray competing risks regression analyses modelled association between cancer-specific mortality (PCSM).The 5-year PCSM rates for 8, were 6.3%, 6.6%, 13.5%, 13.9%, respectively (P < 0.001). Patients had up a two-fold increased risk of (adjusted hazard ratio [AHR] 1.89, 95% confidence interval [CI] 1.50-2.38, P 0.001; AHR 2.17, CI 1.99-2.36, 0.001, respectively) compared referent group (Gleason 8). There no difference in vs 0.25).Gleason represents heterogeneous entity distinguishable by primary pattern. The are similar, but that is twice high should be considered poor prognosis disease. Such allowed onto trials seeking highest-risk which test novel aggressive treatment strategies.