Do we need repeat transurethral resection after en bloc resection for pathological T1 bladder cancer?

• DOI: 10.1111/bju.15760
• Publication Date: 2022-04-30T05:12:54Z
• Authors: Takafumi Yanagisawa; Shun Sato; Yasushi Hayashida; Yohei Okada; Kosuke Iwatani; Akihiro Matsukawa; Takahiro Kimura; Hiroyuki Takahashi; Shin Egawa; Shahrokh F. Shariat; Jun Miki
• Keywords: Surgical margin; Resection margin; Margin (machine learning)

To assess the clinical significance of repeat transurethral resection (reTUR) and surgical margin status after en bloc bladder tumour (ERBT) for pathological T1 (pT1) cancer.We retrospectively analysed record 106 patients with pT1 high-grade cancer who underwent ERBT between April 2013 February 2021 at multiple institutions. All specimens were reviewed by a genitourinary pathologist. The primary outcome measures recurrence-free survival (RFS) progression-free (PFS) those without reTUR. We also predictive value on likelihood residual reTUR.A reTUR was performed in 50 patients. 2-year RFS 3-year PFS comparable did not (55.1% vs 59.9%, P = 0.6, 80.6% 82.6%, respectively). No patient upstaged to pT2 Regarding status, there no recurrences original site 51 negative horizontal margins. Cox proportional hazard analysis revealed that positive vertical an independent prognostic factor worse PFS. On reTUR, six pTa/is residues detected margin, three one or other adverse features.A appears improve either recurrence progression. Surgical affects prognosis outcomes. A can be omitted margins; margins, should remain standard until proven otherwise.