Caveolin‐1 influences epithelial collective cell migration via FMNL2 formin

• DOI: 10.1111/boc.202000116
• Publication Date: 2020-11-10T21:06:52Z
• Authors: Hiroko Katsuno‐Kambe; Robert G. Parton; Alpha S. Yap; Jessica L. Teo
• Keywords: Formins; Caveolin 1

Background Information Epithelial collective cell migration requires the intrinsic locomotor activity of cells to be coordinated across populations. This coordination is governed by presence cell–cell adhesions as well cooperative behaviour within monolayer. Results Here, we report a role for Caveolin‐1 (CAV1) in epithelial migration. CAV1 depletion reduced migratory AML12 liver when grown monolayers, but not individual cells. suggested that component process which multicellular collectivity regulates motility. The correlation length velocity was increased RNAi, possible sign jamming. However, RNAi migration, even monolayers were allowed migrate into unconfined spaces. defect ameliorated simultaneous FMNL2 formin, whose cortical recruitment Conclusions We therefore suggest modulates intraepithelial motility controlling availability FMNL2. Significance Although has been observed multiple contexts both vivo and vitro , inherent coupling between monolayer remain incompletely understood. Our study highlights regulating motility, an effect involves formin