Protective effects of n‐6 fatty acids‐enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor

• DOI: 10.1111/bph.12957
• Publication Date: 2014-10-09T02:37:20Z
• Authors: T Gobbetti; S Ducheix; P le Faouder; T Perez; F Riols; J Boue; J Bertrand‐Michel; M Dubourdeau; H Guillou; M Perretti; N Vergnolle; N Cenac
• Keywords: Lipoxin; Intestinal mucosa

Long-term intake of dietary fatty acids is known to predispose chronic inflammation, but their effects on acute intestinal ischaemia/reperfusion (I/R) injury unknown. The aim this study was determine the consequences a diet rich in n-3 or n-6 polyunsaturated (PUFA) I/R-induced damage.Mice were fed three different isocaloric diets: balanced used as control and two PUFA-enriched diets, providing either high levels PUFA. Intestinal evaluated after I/R. PUFA metabolites quantitated tissues by LC-MS/MS.In diet-fed mice, I/R caused inflammation increased COX lipoxygenase-derived compared with sham-operated animals. Lipoxin A4 (LxA4 ) significantly selectively ischaemia. Animals did not display inflammatory profile following In contrast, decreased group level LxA4 post-ischaemia mice. Blockade receptor (Fpr2), prevented anti-inflammatory associated diet.This indicates that n-6, n-3, PUFAs provides significant protection against damage demonstrates endogenous production can be influenced diet.