Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium‐induced colitis in mice

• DOI: 10.1111/bph.14424
• Publication Date: 2018-06-26T23:29:00Z
• Authors: Meijing Liu; Guohui Zhang; Chunge Zheng; Meng Song; Fangle Liu; Xiaotao Huang; Shasha Bai; Xinan Huang; Chaozhan Lin; Chenchen Zhu; Yingjie Hu; Suiqing Mi; Changhui Liu
• Keywords: Pregnane X receptor; NFAT

Activation of the human pregnane X receptor (PXR; NR1I2) has potential therapeutic uses for inflammatory bowel disease (IBD). Imperatorin (IMP), a naturally occurring coumarin, is main bioactive ingredient Angelica dahurica Radix, which regularly used to treat common cold and intestinal disorders. However, there are no data on protective effects IMP against IBD.