Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis

• DOI: 10.1111/bph.14967
• Publication Date: 2019-12-28T01:49:04Z
• Authors: Chengyu Yin; Boyu Liu; Ping Wang; Xiaojie Li; Yuanyuan Li; Xiaoli Zheng; Yan Tai; Chuan Wang; Boyi Liu
• Keywords: Eucalyptol; Proinflammatory cytokine; Inflammatory arthritis

Background and Purpose Gout arthritis, which is provoked by monosodium urate (MSU) crystal accumulation in the joint periarticular tissues, induces severe pain affects quality of life patients. Eucalyptol (1,8‐cineol), principal component essential oils eucalyptus leaves, known to possess anti‐inflammatory analgesic properties. We aimed examine therapeutic effects eucalyptol on gout arthritis related mechanisms. Experimental Approach A mouse model was established via MSU injection into ankle joint. Ankle oedema, mechanical allodynia, neutrophil infiltration, oxidative stress, NLRP3 inflammasome, TRPV1 expression were examined. Key Results attenuated MSU‐induced allodynia oedema dose‐dependently, with effectiveness similar indomethacin. reduced inflammatory cell infiltrations tissues. inhibited inflammasome activation pro‐inflammatory cytokine production induced tissues vivo. stress RAW264.7 cells vitro as well vivo, indicated an increase activities antioxidant enzymes reduction ROS. up‐regulation dorsal root ganglion neurons innervating ankle. The vivo IL‐1β, mimicked treating MSU‐injected mice antioxidants. Conclusion Implications alleviates inflammation mechanisms possibly involving anti‐oxidative effect. other antioxidants may represent promising options for arthritis.