Amelioration of elastase‐induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice

• DOI: 10.1111/bph.15057
• Publication Date: 2020-03-23T01:10:30Z
• Authors: Athanasios Fysiko...; Michael Seimetz; Stefan Hadzic; Fenja Knoepp; Cheng‐Yu Wu; Kathrin Malkmus; Jochen Wilhelm; Alexandra Pichl; Mariola Bednorz; Elsa Tadele Roxlau; Hossein A. Ghofrani; Natascha Sommer; Mareike Gierhardt; Ralph T. Schermuly; Werner Seeger; Friedrich Grimminger; Norbert Weissmann; Simone Kraut
• Keywords: Pulmonary emphysema

Chronic obstructive pulmonary disease, encompassing chronic airway obstruction and lung emphysema, is a major worldwide health problem severe socio-economic burden. Evidence previously provided by our group has shown that inhibition of inducible NOS (iNOS) prevents development mild emphysema in mouse model tobacco smoke exposure can even trigger regeneration. Moreover, we could demonstrate hypertension not only abolished cigarette smoke-exposed iNOS-/- mice but also precedes development. Possible regenerative effects pharmacological iNOS more models dependent on smoke, however, are hitherto unknown.We have established using single dose porcine pancreatic elastase or saline, intratracheally instilled C57BL/6J mice. Emphysema, as well was determined both structural functional measurements.Our data revealed (i) fully after 21 days, with the same degree 28 days post instillation, (ii) stable for at least 12 weeks (iii) evident, contrast to models, Oral treatment inhibitor N(6)-(1-iminoethyl)-l-lysine (L-NIL) started establishment continued weeks. This resulted significant regeneration, evident improvement reversal hypertension.Our indicate potential new therapeutic target treat associated hypertension.This article part themed issue Risk factors, comorbidities, comedications cardioprotection. To view other articles this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.1/issuetoc.