Inhibition of TRPM8 function by prostacyclin receptor agonists requires coupling to Gq/11 proteins

• DOI: 10.1111/bph.16295
• Publication Date: 2023-12-04T06:01:24Z
• Authors: Cosmin Trif; Alexandra‐Maria B...; Alexandra Manolache; Sorina Andreea An...; Debora‐Elena Huţanu; Teodora Stratulat; Rodica Badea; George Oprita; Tudor Selescu; Stefana M. Petrescu; Marco Sisignano; Stefan Offermanns; Alexandru Babes; Sorin Tunaru
• Keywords: TRPM8

The TRPM8 ion channel is involved in innocuous cold sensing and has a potent anti-inflammatory action. Its activation by lower temperature or chemical agonists such as menthol icilin induces analgesic effects, reversing hypersensitivity reducing chronic pain. On the other hand, prostacyclin (PGI