Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer‐initiating cells

• DOI: 10.1111/cas.12362
• Publication Date: 2014-01-23T09:21:21Z
• Authors: Rena Morita; Satoshi Nishizawa; Toshihiko Torigoe; Akari Takahashi; Yasuaki Tamura; Tomohide Tsukahara; Takayuki Kanaseki; Alice Sokolovskaya; Vitaly Kochin; Toru Kondo; Satoshi Hashino; Masahiro Asaka; Isao Hara; Yoshihiko Hirohashi; Noriyuki Sato
• Keywords: CTL*; Cancer Immunotherapy; Adoptive Cell Transfer

The aim of the present study was to establish cancer stem‐like cell/cancer‐initiating cell ( CSC / CIC )‐targeting immunotherapy. are thought be essential for tumor maintenance, recurrence and distant metastasis. Therefore they reasonable targets therapy. In study, we found that a heat shock protein HSP ) 40 family member, DnaJ (Hsp40) homolog, subfamily B, member 8 DNAJB 8), is preferentially expressed in derived from colorectal CRC cells rather than non‐ . Overexpression enhanced expression stem markers tumorigenicity, indicating has role A 8‐specific cytotoxic T lymphocyte CTL response could induced by 8‐derived antigenic peptide. clone specific peptide showed higher killing activity compared with , adoptive transfer into an antitumor effect vivo Taken together, results indicate novel target ‐targeting