Functional polymorphisms in the NPAS2 gene are associated with overall survival in transcatheter arterial chemoembolization‐treated hepatocellular carcinoma patients

• DOI: 10.1111/cas.12428
• Publication Date: 2014-04-23T10:20:40Z
• Authors: Peng Yuan; Shen Wang; Feng Zhou; Shaogui Wan; Yefa Yang; Xiaojun Huang; Zhaohui Zhang; Yong Zhu; Hongxin Zhang; Jinliang Xing
• Keywords: Transcatheter arterial chemoembolization

The functional abnormality of circadian regulation genes is involved in the development and progression hepatocellular carcinoma (HCC). However, association between single nucleotide polymorphisms (SNPs) gene NPAS2 overall survival HCC patients treated with transcatheter arterial chemoembolization (TACE) has never been investigated. Six SNPs were genotyped using Sequenom iPLEX genotyping system a cohort 448 unresectable Chinese TACE. Multivariate Cox proportional hazards model Kaplan-Meier curves used for prognosis analysis. We found that two SNPs, rs1053096 rs2305160, showed significant associations death risk recessive (hazard ratio [HR] = 1.48; 95% confidence interval [CI], 1.13-1.94; P 0.004) dominant (HR 1.63; CI, 1.29-2.07; < 0.001), respectively. Moreover, we observed cumulative effect these on survival, indicating trend increasing number unfavorable genotypes (P 0.001). Compared without any genotypes, HRs one 1.41 (95% 1.10-1.82; 0.007) 2.09 1.46-2.97, haplotype diplotype analyses further characterized genotype patients. Our results first time suggest may serve as an independent prognostic marker