Tumor‐suppressive microRNA‐145 induces growth arrest by targeting SENP1 in human prostate cancer cells

• DOI: 10.1111/cas.12626
• Publication Date: 2015-02-03T04:48:53Z
• Authors: Chunyang Wang; Weiyang Tao; Shaobin Ni; Qiyin Chen; Zhongshan Zhao; Li Ma; Yiming Fu; Zhixing Jiao
• Keywords: Male; 0301 basic medicine; Mice, Inbred BALB C; Binding Sites; Mice, Nude; Prostatic Neoplasms; Original Articles; Cell Cycle Checkpoints; 3. Good health; Gene Expression Regulation, Neoplastic; Cysteine Endopeptidases; Mice; MicroRNAs; 03 medical and health sciences; Cell Transformation, Neoplastic; Cell Line, Tumor; Endopeptidases; Animals; Humans; Female; 3' Untranslated Regions; Neoplasm Transplantation; Cell Proliferation; Protein Binding

Prostate cancer ( PC a) prevails as the most commonly diagnosed malignancy in men and third leading cause of cancer‐related deaths developed countries. One distinct characteristics prostate is overexpression small ubiquitin‐like modifier SUMO )‐specific protease 1 SENP 1), upregulation contributes to malignant progression cell proliferation a. Previous studies have shown that expression micro RNA ‐145 (mi ‐145) was extensively deregulated a lines primary clinical samples. Independent target prediction methods indicated 3′‐untranslated region mRNA potential miR‐145. Here we found low miR‐145 correlated with high line ‐3. The transient introduction caused cycle arrest ‐3 cells, opposite effect observed when inhibitor transfected. Further revealed regulative vitro . Micro also suppressed tumor formation vivo nude mice. Taken together, plays an important role tumorigenesis through interfering 1.