Long non‐coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR‐335‐5p in osteosarcoma cells

• DOI: 10.1111/cas.13201
• Publication Date: 2017-02-16T04:57:17Z
• Authors: Yong Wang; Tao Yang; Zhen Zhang; Ming Lu; Wei Zhao; Xiandong Zeng; Weiguo Zhang
• Keywords: Competing Endogenous RNA

Long non‐coding RNA (lnc ) have been the focus of increasing attention due to role they play in many diseases, including osteosarcoma. The function taurine upregulated gene 1 ( TUG 1) and its mechanism osteosarcoma remain unclear. In our research, we found that was elevated correlated with a poor prognosis patients. addition, following functional experiment showed decreased could remarkably inhibit cell migration invasion, indicating functioned as an oncogene Moreover, revealed Rho‐associated coiled‐coil‐containing protein kinase ROCK 1), metastasis‐related targeted by micro ‐335‐5p (miR‐335‐5p), had same miR‐335‐5p combining site. subsequent luciferase assay verified target miR‐335‐5p. Furthermore, results real‐time quantitative PCR affect each other's expression. respectively. Finally, affirmed affected expression 1‐mediated migration/invasion working competitive endogenous (ce via summary, findings this study, based on ce theory, research foundation 1, taking new study point, provide insight into molecular‐level reversing invasion