DEP domain containing 1 predicts prognosis of hepatocellular carcinoma patients and regulates tumor proliferation and metastasis

• DOI: 10.1111/cas.13867
• Publication Date: 2018-11-12T08:10:11Z
• Authors: Di Qu; Feng Cui; Dan Lu; Yu Yang; Yuqing Xu
• Keywords: Male; Mice, Inbred BALB C; 0303 health sciences; Carcinoma, Hepatocellular; Gene Expression Profiling; GTPase-Activating Proteins; Liver Neoplasms; Mice, Nude; Original Articles; Middle Aged; Prognosis; Neoplasm Proteins; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; HEK293 Cells; RNAi Therapeutics; Cell Line, Tumor; Animals; Humans; Female; RNA Interference; Neoplasm Metastasis; Cell Proliferation

DEP domain containing 1 ( DEPDC 1) protein is a novel oncoantigen upregulated in multiple types of cancers which present oncogenic activity and high immunogenicity. However, the function therapeutic potential hepatocellular carcinoma HCC ) remain unclear. In study, we showed that was frequently associated with cancer diagnosis poor prognosis for patients. Moreover, promotes cell proliferation vitro as well carcinogenesis vivo. Notably, overexpression also increases neoplasm metastasis ability cells both vivo vitro. Gene set enrichment analysis results expression positively correlated K‐ RAS signal pathway, pathways WNT /β‐catenin all are closely specific cancer‐related gene sets. Our study provides basis further investigation molecular mechanism by development .