Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)‐182/miR‐93‐leukemia inhibitory factor receptor pathway

• DOI: 10.1111/cas.14131
• Publication Date: 2019-07-13T08:39:23Z
• Authors: Lin Wang; Yingkuan Liang; Qixing Mao; Wenjie Xia; Bing Chen; Hongyu Shen; Lin Xu; Feng Jiang; Gaochao Dong
• Keywords: Circular RNA; Competing Endogenous RNA

Abstract In recent years, circular RNA s (circ s) have been revealed to important roles in carcinogenesis. Metastasis is the leading cause of lung adenocarcinoma ( LUAC ) death. However, contributions circ metastasis remain largely unknown. Based on circBase data and our biobank tissues, we identified CRIM 1 (a derived from exons 2, 3 4 gene, hsa_circ_0002346) as having a significantly decreased expression samples compared with matched normal control samples. Both vivo vitro experiments that suppresses invasion . precipitation s, luciferase reporter assay, biotin‐coupled micro capture were carried out investigate Ago 2‐dependent interaction microRNA (miR)‐93/miR‐182. Mechanistically, found could promote leukemia inhibitory factor receptor, well‐known tumor suppressor, by sponging miR‐93 miR‐182. clinical pathological analyses, downregulation was correlated lymphatic TNM stage, which served an independent risk for overall survival patients Our study showed inhibits cancer cells, makes it potential therapeutic target.