Capn4 is induced by and required for Epstein‐Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP‐1 signaling

• DOI: 10.1111/cas.14227
• Publication Date: 2019-11-06T05:58:05Z
• Authors: Peichan Zheng; Xiong Chen; Jianqin Xie; Xi Chen; Shanshan Lin; Lixiang Ye; Lingfan Chen; Jing Lin; Xiangbin Yu; Ming Zheng
• Keywords: Ectopic expression

Abstract Capn4, also known as CapnS1, is a member of the calpain family, which plays crucial role in maintaining activity and function calpain. We previously reported that Capn4 an essential migration nasopharyngeal carcinoma (NPC) cells through regulation (MMP‐2) by nuclear factor‐kappa B activation. Epstein‐Barr virus latent membrane protein 1 (LMP1) closely related to malignant functions NPC; however, relationship between LMP1 NPC remain unclear. Immunohistochemical studies showed level expression was high both primary metastatic tissues, with significantly positive correlation. further found able upregulate promoter dose‐dependent way C‐terminal activation region (CTAR)1 CTAR2 domains activate AP‐1. Moreover, we activated AP‐1 ERK/JNK phosphorylation. These findings indicate coordination promotes actin rearrangement and, ultimately, cellular migration. results show enhances increasing involving ERK/JNK/AP‐1 signaling. Therapeutically, additional more specific targeted inhibitors could be exploited treat NPC.