miR‐30e‐5p represses angiogenesis and metastasis by directly targeting AEG‐1 in squamous cell carcinoma of the head and neck

• DOI: 10.1111/cas.14259
• Publication Date: 2019-11-28T13:56:05Z
• Authors: Shuiting Zhang; Guo Li; Chao Liu; Shanhong Lu; Qiancheng Jing; Xiyu Chen; Hua Zheng; Huiling Ma; Diekuo Zhang; Shuling Ren; Zhe Shen; Yunyun Wang; Zhaoyi Lu; Donghai Huang; Pingqing Tan; Jie Chen; Xin Zhang; Yuanzheng Qiu; Yong Liu
• Keywords: Male; 0301 basic medicine; Lung Neoplasms; Neovascularization, Pathologic; Squamous Cell Carcinoma of Head and Neck; Membrane Proteins; RNA-Binding Proteins; Original Articles; Prognosis; Survival Analysis; 3. Good health; Gene Expression Regulation, Neoplastic; Mice; MicroRNAs; 03 medical and health sciences; Head and Neck Neoplasms; Cell Line, Tumor; Animals; Humans; Female; Neoplasm Transplantation; Cell Proliferation

Abstract Metastasis is a critical determinant for the treatment strategy and prognosis in patients with squamous cell carcinoma of head neck (SCCHN). However, mechanisms underlying SCCHN metastasis are poorly understood. Our study sought to determine key microRNA their functional involved metastasis. For The Cancer Genome Atlas (TCGA) data analysis, quantitative PCR was used quantify level miR‐30e‐5p its clinical significance further analyzed. A series vitro vivo experiments were applied effects target AEG‐1 on mechanism investigation revealed that implicated angiogenesis mediated by miR‐30e‐5p. Overall, our confirms valuable predictive biomarker potential therapeutic