CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF‐β signaling

• DOI: 10.1111/cas.14673
• Publication Date: 2020-10-02T16:04:38Z
• Authors: Tetsuro Taki; Yukihiro Shiraki; Atsushi Enomoto; Liang Weng; Chen Chen; Naoya Asai; Yoshiki Murakumo; Kohei Yokoi; Masahide Takahashi; Shinji Mii
• Keywords: Male; 0303 health sciences; Lung Neoplasms; Original Articles; Adenocarcinoma; Middle Aged; GPI-Linked Proteins; Prognosis; Neoplasm Proteins; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; Latent TGF-beta Binding Proteins; Antigens, CD; Cell Movement; Cell Line, Tumor; Animals; Humans; Clustered Regularly Interspaced Short Palindromic Repeats; Female; Neoplasm Invasiveness; Aged; Cell Proliferation

Stromal invasion is considered an important prognostic factor in patients with lung adenocarcinoma. The mechanisms underlying the formation of tumor stroma and stromal have been studied lung; however, they are still unclear. CD109 a glycosylphosphatidylinositol-anchored glycoprotein highly expressed several types human malignant tumors including cancers. In this study, we investigated vivo functions protein tumors. Initially, identified association between higher expression adenocarcinoma significantly worse prognosis, according to immunohistochemical analysis. We also showed that deficiency reduced area invasive lesions genetically engineered CD109-deficient mouse model, which correlated results observed Furthermore, latent TGF-β binding protein-1 (LTBP1) as CD109-interacting using mass spectrometry confirmed their interaction by co-immunoprecipitation. Importantly, increased enhanced activation presence LTBP1. Therefore, these data suggest significance regulation signaling through LTBP1 reveal importance levels promoting cancer cell proliferation, migration, invasion, thus predicting outcome suffering from could be potential therapeutic target for disease.