Aberrant expression of junctional adhesion molecule‐A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155

Adult 0301 basic medicine Uterine Cervical Neoplasms Receptors, Cell Surface Original Articles Adenocarcinoma Middle Aged 3. Good health Gene Expression Regulation, Neoplastic 03 medical and health sciences Humans Receptors, Virus Female Cell Adhesion Molecules
DOI: 10.1111/cas.14734 Publication Date: 2020-11-13T13:52:46Z
ABSTRACT
Abstract Recent studies have shown that aberrant expression of tight junction proteins (TJP) contributes to malignant potential various cancers. In the present study, we investigated junctional adhesion molecule‐A (JAM‐A), one transmembrane TJP, in uterine cervical adenocarcinoma and significance its for malignancy. Immunohistochemistry on human surgical specimens showed JAM‐A was aberrantly expressed neoplastic regions including situ (AIS). Knockout significantly suppressed cell proliferation colony‐forming migration abilities. We also an antibody specific extracellular region reduced ability loss increased drug sensitivity cells. Based a comprehensive proteome analysis, found poliovirus receptor (PVR/CD155) regulated by formed physical interaction with JAM‐A. specimens, PVR/CD155 correlated some clinicopathological features prognosis adenocarcinoma. Interestingly, most PVR/CD155‐positive cases high level JAM‐A, patients pattern positive/JAM‐A had shorter periods relapse‐free survival ( P = .00964) overall .0204) than those other patients. Our observations suggest promotes malignancy regulation PVR/CD155, is therefore therapeutic target this
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