Aberrant expression of junctional adhesion molecule‐A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155

• DOI: 10.1111/cas.14734
• Publication Date: 2020-11-13T13:52:46Z
• Authors: Taro Murakami; Akira Takasawa; Kumi Takasawa; Taishi Akimoto; Tomoyuki Aoyama; Kazufumi Magara; Yuki Saito; Misaki Ota; Daisuke Kyuno; Soh Yamamoto; Tadashi Hasegawa; Tsuyoshi Saito; Makoto Osanai
• Keywords: Adult; 0301 basic medicine; 0303 health sciences; Uterine Cervical Neoplasms; Receptors, Cell Surface; Original Articles; Adenocarcinoma; Middle Aged; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Humans; Receptors, Virus; Female; Cell Adhesion Molecules

Abstract Recent studies have shown that aberrant expression of tight junction proteins (TJP) contributes to malignant potential various cancers. In the present study, we investigated junctional adhesion molecule‐A (JAM‐A), one transmembrane TJP, in uterine cervical adenocarcinoma and significance its for malignancy. Immunohistochemistry on human surgical specimens showed JAM‐A was aberrantly expressed neoplastic regions including situ (AIS). Knockout significantly suppressed cell proliferation colony‐forming migration abilities. We also an antibody specific extracellular region reduced ability loss increased drug sensitivity cells. Based a comprehensive proteome analysis, found poliovirus receptor (PVR/CD155) regulated by formed physical interaction with JAM‐A. specimens, PVR/CD155 correlated some clinicopathological features prognosis adenocarcinoma. Interestingly, most PVR/CD155‐positive cases high level JAM‐A, patients pattern positive/JAM‐A had shorter periods relapse‐free survival ( P = .00964) overall .0204) than those other patients. Our observations suggest promotes malignancy regulation PVR/CD155, is therefore therapeutic target this