Squalene synthase predicts poor prognosis in stage I‐III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression

• DOI: 10.1111/cas.15248
• Publication Date: 2021-12-23T03:34:54Z
• Authors: Huihong Jiang; Erjiang Tang; Ying Chen; Hailong Liu; Yun Zhao; Moubin Lin; Luwei He
• Keywords: Squalene monooxygenase; Squalene

Colon adenocarcinoma (COAD) is one of the most prevalent malignancies, with poor prognosis and lack effective treatment targets. Squalene synthase (FDFT1) an upstream enzyme squalene epoxidase (SQLE) in cholesterol biosynthesis. In a previous study, we revealed that SQLE promotes colon cancer cell proliferation vitro vivo. Here, investigate prognostic value FDFT1 stage I-III COAD explore potential underlying mechanisms. was significantly upregulated positively correlated differentiation advanced tumor stage. High expression independent predictor overall relapse-free survival, nomograms based on could effectively identify patients at high risk outcome. accelerated promoted growth. Lack resulted accumulating NAT8 D-pantethine to lower reactive oxygen species levels inhibit proliferation. Moreover, combined inhibition induced greater suppressive effect growth than single inhibition. Taken together, these results indicate predicts has tumor-promoting through regulating D-pantethine. Targeting both more promising therapy their for COAD.