Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer

• DOI: 10.1111/cas.15613
• Publication Date: 2022-10-12T05:51:40Z
• Authors: Jing Cao; Xiaobo Wang; Shouman Wang; Zihua Chen; Jianing Tang
• Keywords: Estrogen receptor alpha; Estrogen receptor beta

Breast cancer is a major cause of cancer-related morbidity and mortality in women. Estrogen receptor-positive breast accounts for roughly 70%-80% tumors, estrogen receptor alpha (ERα) has been considered as key driver promoting progression. In the present study, we identified USP37 novel modulator modulating ERα ubiquitination stability. The expression was upregulated ERα-positive correlated with protein level. High associated unfavorable prognosis. depletion resulted significantly decreased level, target genes well response element activity cells. Further mechanistic study revealed interaction between ERα: regulated signaling through stability instead gene expression, which it stabilized via inhibiting K48-specific polyubiquitination process. Additionally, led to growth inhibition cell cycle arrest cells, could be further rescued by overexpression. Overall, our proposed post-translational mechanism Targeting may proved promising strategy patients cancer.