Senescent CD8+ T cells acquire NK cell‐like innate functions to promote antitumor immunity

• DOI: 10.1111/cas.15824
• Publication Date: 2023-04-26T04:30:37Z
• Authors: Toshio Kakuda; Junpei Suzuki; Yuko Matsuoka; Tadahiko Kikugawa; Takashi Saika; Masakatsu Yamashita
• Keywords: Killer Cells, Natural; 0301 basic medicine; Mice; Aging; 03 medical and health sciences; Melanoma, Experimental; Animals; ORIGINAL ARTICLES; CD8-Positive T-Lymphocytes; Adaptive Immunity

It has been suggested that aging of the immune system (immunosenescence) results in a decline acquired response, which is associated with an increase age-related tumorigenesis. T-cell senescence plays critical role immunosenescence and involved function, increases susceptibility to certain cancers. However, it shown CD8+ T cells senescent phenotype acquire natural killer (NK) cell-like function are tumor elimination. Therefore, immunity remains be elucidated. In this study, we investigated immunity. murine model transferred B16 melanoma, lung metastasis was significantly suppressed aged mice (age ≥30 weeks) comparison young 6-10 weeks). We evaluated cytotoxic activity vitro found from activated exhibited increased those mice. used Menin-deficient effector as for expression NK receptors were upregulated cells. Furthermore, can eliminate antigen-independent manner. These suggest may contribute elderly by acquiring NK-like innate functions, such activity.