Pan‐immune‐inflammation value predicts immunotherapy response and reflects local antitumor immune response in rectal cancer

• DOI: 10.1111/cas.16400
• Publication Date: 2024-11-27T10:14:57Z
• Authors: Qianyu Wang; Wentao Zhong; Yi Xiao; Guole Lin; Junyang Lu; Lai Xu; Guannan Zhang; Aijun Liu; Junfeng Du; Bin Wu
• Keywords: 0301 basic medicine; 03 medical and health sciences; ORIGINAL ARTICLE

Abstract The pan‐immune‐inflammation value reflects the systemic inflammatory response, and tumor‐infiltrating lymphocytes indicate a local immune response in rectal cancer. However, association between as indicated by value, responses cancer remains unclear. This study analyzed 915 treatment‐naïve patients from Peking Union Medical College Hospital PLA General (PLAGH) cohorts who underwent radical surgery to investigate relationship responses. Lower was significantly associated with improved disease‐free survival cancer‐specific survival. Multivariate Cox regression models identified an independent prognostic factor. In PLAGH cohort, low values had higher cell levels, activated pathways, increased expression of checkpoint genes according RNA sequencing. Hematoxylin eosin staining immunohistochemical analysis revealed that lower lymphocyte density, more mature tertiary lymphoid structures, CD8 + T cells, elevated human antigen class I expression. Conversely, high exhibited pathways linked tumor progression, such angiogenesis, epithelial–mesenchymal transition, hypoxia, KRAS signaling, TGF‐ß signaling. Among receiving anti‐PD‐1 therapy, responders pre‐ post‐treatment values. is reliable marker distinct microenvironment characteristics can effectively predict survival, immunotherapy.