Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity against Anopheles arabiensis

• DOI: 10.1111/cbdd.12823
• Publication Date: 2016-07-21T07:45:17Z
• Authors: Chandrashekharapp...; Katharigatta N. V...; Raquel M. Gleiser; Abeen Chetram; Basavaraj Padmashali; Rashmi S. Kulkarni; Rashmi Venugopala; Bharti Odhav
• Keywords: Spectrometry, Mass, Electrospray Ionization; Proton Magnetic Resonance Spectroscopy; Indolizines; Water; SYNTHESIS; 01 natural sciences; 0104 chemical sciences; INDOLIZINE ANALOGUES; https://purl.org/becyt/ford/1.6; Larva; Anopheles; Spectroscopy, Fourier Transform Infrared; Solvents; Animals; Carbon-13 Magnetic Resonance Spectroscopy; CHARACTERIZATION; LARVICIDAL ACTIVITY; https://purl.org/becyt/ford/1; Chromatography, Liquid

Greener synthesis of a series of novel indolizine analogues have been achieved by the cyclization of aromatic cycloimmonium ylides with electron‐deficient alkynes in the presence of water as the base and solvent at 80 °C. Yield of the title compounds was good and reactions performed were eco‐friendly. The structures of these newly synthesized compounds have been confirmed by spectroscopic techniques such as FTIR, NMR, LC‐MS, and elemental analysis. Characterized title compounds were evaluated for larvicidal activity against Anopheles arabiensis by standard WHO larvicidal assay using Temefos as standard at 4 μg/mL. Title compounds 2e, 2f, and 2g emerged as promising larvicidal agents.