A comparison inhibitory effects of cisplatin and MNPs‐PEG‐cisplatin on the adhesion capacity of bone metastatic breast cancer

• DOI: 10.1111/cbdd.12985
• Publication Date: 2017-03-24T15:49:08Z
• Authors: Mohammad Javad Mo...; Fatemeh Koohpeima; Hadi Mohammadi
• Keywords: Zeta potential

To date, high mortality in women due to malignancy breast cancer related the metastasis bone is a significant challenge. As, magnetic nanoparticles (MNPs) conjugated with biocompatible polymers was employed for delivery of some hydrophobic anticancer agents, main aim current research assess whether cisplatin-loaded MNPs enhanced effect free cisplatin cells. decorated PEG were synthesized by an improved coprecipitation technique, and then loaded onto via simple mixing method. Afterward, its morphology, size, chemical structure, property, hydrodynamic diameter, zeta potential, crystal structure characterized scanning transmittance electron microscopy, Fourier transforms infrared spectroscopy, vibrating sample magnetometer, dynamic light scattering, X-ray powder diffraction flame atomic absorption spectroscopy respectively. Additionally, effects MNPs-PEG-cisplatin on viability, migration adhesion capacity T47D cells investigated evaluating α2-integrin β1-integrin; mRNAs assessed real-time RT-PCR. Consequently, vitro assay results showed considerable dose-dependent inhibitory proliferation, migration, Finally, shown that strongly increased compared cell line.