A Methylome‐Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

• DOI: 10.1111/cdev.12957
• Publication Date: 2017-09-20T06:28:41Z
• Authors: Edward D. Barker; Esther Walton; Charlotte A.M. Cecil; Richard Rowe; Sara R. Jaffee; Barbara Maughan; Thomas G. O'Connor; Argyris Stringaris; Alan J. Meehan; Wendy McArdle; Caroline L. Relton; Tom R. Gaunt
• Keywords: Empirical Articles; Male; 0301 basic medicine; Attention Deficit Hyperactivity Disorder; DNA methylation; Adolescent; 610; ALSPAC; DNA Methylation; Irritability; Irritable Mood; Oppositional Defiant Disorder; Cohort Studies; 03 medical and health sciences; Attention Deficit Disorder with Hyperactivity; Attention Deficit and Disruptive Behavior Disorders; Humans; Headstrong; Female; Symptom Assessment; Child

In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), the ODD subdimensions irritable headstrong; (b) common biological pathways, indexed by methylation, attention deficit hyperactivity (ADHD); (c) genetic influence on methylation; (d) prenatal risk exposure associations. Methylome‐wide significant were identified for headstrong, but not irritable. Overlap analysis indicated correlates ODD, ADHD. in headstrong was (to a degree) genetically influenced. associated with exposures maternal anxiety (headstrong) cigarette smoking (ODD headstrong).