Stability of Aging‐ and Cognition‐Related Methylation Profile Scores Across Two Waves in Children and Adolescents

• DOI: 10.1111/cdev.14239
• Publication Date: 2025-04-04T07:27:19Z
• Authors: Abby J. deSteiguer; Laurel Raffington; Aditi Sabhlok; Peter Tanksley; Elliot M. Tucker‐...; K. Paige Harden
• Keywords: Longitudinal Study

DNA-methylation profile scores (MPSs) index biology relevant for lifelong physical and cognitive health, but information on their longitudinal stability in childhood is lacking. Using two waves of data collected from 2014 to 2022 (Mlag between = 2.41 years) N 407 participants (Mage 12.05 years, 51% female, 60% White), test-retest correlations were estimated four salivary MPSs related aging (PhenoAgeAccel, GrimAgeAccel, DunedinPACE), function (Epigenetic-g). varied (test-retest rs 0.38 0.76). did not differ children exposed the COVID-19 pandemic, race-ethnic sex differences apparent. Further research necessary understand which environmental perturbations impact trajectories when are most sensitive those impacts.