Lipopolysaccharide suppresses IgE‐mast cell‐mediated reactions

• DOI: 10.1111/cea.13013
• Publication Date: 2017-08-21T14:42:39Z
• Authors: N. Wang; M. McKell; A. Dang; A. Yamani; L. Waggoner; S. Vanoni; T. Noah; D. Wu; A. Kordowski; J. Köhl; K. Hoebe; S. Divanovic; S. P. Hogan
• Keywords: Lipopolysaccharides; Mice, Knockout; Receptors, IgE; Immunoglobulin E; Cell Degranulation; Interleukin-10; 3. Good health; Toll-Like Receptor 4; Disease Models, Animal; Mice; 03 medical and health sciences; 0302 clinical medicine; Gene Expression Regulation; Hematocrit; Macrophages, Peritoneal; Animals; Calcium; Mast Cells; Anaphylaxis; Signal Transduction

Clinical and experimental analyses have identified a central role for IgE/FcεRI/mast cells in promoting IgE-mediated anaphylaxis. Recent data from human studies suggest that bacterial infections can alter susceptibility to