Effects of personal air pollution exposure on asthma symptoms, lung function and airway inflammation

• DOI: 10.1111/cea.13130
• Publication Date: 2018-03-11T07:56:35Z
• Authors: L. Chambers; J. Finch; K. Edwards; A. Jeanjean; R. Leigh; S. Gonem
• Keywords: Adult; Male; Environmental Exposure; Middle Aged; 01 natural sciences; 333; Asthma; Respiratory Function Tests; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; 13. Climate action; Air Pollution; 11. Sustainability; Humans; Female; Disease Susceptibility; Symptom Assessment; Aged; 0105 earth and related environmental sciences

There is evidence that air pollution increases the risk of asthma hospitalizations and healthcare utilization, but effects on day-to-day control are not fully understood.We undertook a prospective single-centre panel study to test hypothesis personal exposure associated with symptoms, lung function airway inflammation.Thirty-two patients clinical diagnosis were provided monitor (Cairclip NO2 /O3 ) which was kept or around their person throughout 12-week follow-up period. Ambient levels particulate matter modelled based upon satellite imaging data. Directly measured ozone, obtained from monitoring station in central Leicester. Participants made daily electronic records peak expiratory flow exhaled nitric oxide. Spirometry symptom questionnaires completed at fortnightly visits. Data analysed using linear mixed models cross-correlation.Cairclip data good quality clear diurnal variability missing rate approximately 20%. We unable detect consistent relationships between outcomes group as whole. In an exploratory subgroup analysis, total oxidant increased daytime symptoms women men.We did find compelling impacts unselected population, further studies required larger populations higher levels. Women may be more susceptible than men pollution, observation requires confirmation future studies.