Maternal IgG impairs the maturation of offspring intrathymic IL‐17‐producing γδT cells: Implications for murine and human allergies

• DOI: 10.1111/cea.13393
• Publication Date: 2019-03-31T12:43:00Z
• Authors: Marília G. de‐Oli...; Aline A. L. Lira; Fábio R. Sgnotto; Amanda H. S. Inoue; Ludimila S. Santos; Bernardo Y. Nakam...; Alberto J. S. Duarte; Maria Leite‐de‐Mo...; Jefferson R. Victor
• Keywords: Mice, Knockout; 0301 basic medicine; [SDV.IMM] Life Sciences [q-bio]/Immunology; T-Lymphocytes; Interleukin-17; Receptors, Antigen, T-Cell, gamma-delta; Thymus Gland; 3. Good health; Mice; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Immunoglobulin G; Hypersensitivity; Animals; Humans; Female; Maternal-Fetal Exchange

The precise mechanism involved in the acquisition of IL-17+ profile γδT cells, ligands responsible for this change, and whether default is acquired during intrathymic maturation need to be elucidated.This study aimed evaluate IL-17-producing cells are present airways tolerant offspring from allergen-sensitized mothers possible implication maternal IgG generation these cells.Female mice were immunized or not, allergic response, frequency cell subsets cytokine production analysed by flow cytometry. effects passive vivo transfer purified investigated offspring. A translational approach was employed analyse thymus PBMCs humans.Maternal immunization reduced spontaneous thymus, spleen lung This effect mimicked treatment females with IgG. directly interacted membranes. modulatory human on infant adult peripheral showed similarities murine which rarely reported literature.Together, our results reveal that potentially atopic can influence thymic maturation. Furthermore, we suggest an unprecedented factor cells. These observations may support future development IgG-based immunoregulatory therapeutic strategies.