microRNA‐218‐5p plays a protective role in eosinophilic airway inflammation via targeting δ‐catenin, a novel catenin in asthma

• DOI: 10.1111/cea.13498
• Publication Date: 2019-09-14T02:32:52Z
• Authors: Yuxia Liang; Yuchen Feng; Wenliang Wu; Chenli Chang; Dian Chen; Shengchong Chen; Guohua Zhen
• Keywords: Bronchial hyperresponsiveness

microRNA (miR)-218-5p is involved in cigarette smoke-induced airway inflammation. In our earlier asthma epithelial miRNA profiling data, miR-218-5p was the top 2 down-regulated miRNA. We hypothesize that plays a role inflammation.To unveil of and its target gene inflammation.We measured expression bronchial brushings patients (n = 50) healthy controls 15), analysed correlations between eosinophilia. examined whether CTNND2 miR-218-5p, 12 catenin family members brushings, cultured human (HBE) cells BEAS-2B cells. explored miR-218-5p-CTNND2 pathway using murine model allergic inflammation.Epithelial significantly decreased negatively correlated with eosinophils induced sputum biopsies, other type biomarkers patients. verified (encoding δ-catenin) miR-218-5p. Remarkably, most up-regulated compared 11 patients, IL-13-stimulated HBE Moreover, positively eosinophilia asthma. Airway mmu-miR-218-5p also decreased, Ctnnd2 increased Intriguingly, overexpression suppressed hyperresponsiveness, eosinophilic inflammation up-regulation mouse model. Finally, perturbation or altered chemokine CCL26 cell cultures model.Epithelial protective via targeting CTNND2, novel asthma, suppressing expression.