Association between nasal and nasopharyngeal bacterial colonization in early life and eczema phenotypes

• DOI: 10.1111/cea.13869
• Publication Date: 2021-03-24T07:47:26Z
• Authors: Chen Hu; Liesbeth Duijts; Evelien R. van Meel; Kirsten I. M. Looman; Jessica C. Kiefte...; Luba M. Pardo; DirkJan Hijnen; Suzanne G. M. A. ...; Johan C. de Jongste; Henriette A. Moll; Tamar Nijsten
• Keywords: Male; 0301 basic medicine; Staphylococcus aureus; atopic dermatitis; nasal bacteria; Infant; birth cohort; S. aureus colonization; Nose; Haemophilus influenzae; Dermatitis, Atopic; 3. Good health; 03 medical and health sciences; Streptococcus pneumoniae; Child, Preschool; Nasopharynx; Carrier State; Humans; Female; ORIGINAL ARTICLES; Child; Moraxella catarrhalis

Abstract Background An association has been reported between early life Staphylococcus aureus nasal carriage and higher risk of childhood eczema, but it is unclear whether this relationship causal associations with other bacterial species are unclear. Objective To examine the nasopharyngeal eczema phenotypes, direction any identified. Methods Among 996 subjects a population‐based prospective cohort study, swabs for , Streptococcus pneumoniae Moraxella catarrhalis Haemophilus influenzae were collected cultured from age 6 weeks to years. Never, early, mid‐, late transient persistent phenotypes identified parental‐reported physician‐diagnosed months until 10 Multinomial regression models cross‐lagged applied. Results at was associated an increased (OR (95% CI): 2.69 (1.34, 5.39) 4.17 (1.12, 15.51)). The mostly cross‐sectional, not longitudinal. No influenza observed range 0.71 (0.35, 1.44) 1.77 (0.84, 3.73)). Conclusions Early carriage, eczema. cross‐sectionally associated, longitudinally, making in either unlikely.