DC-SIGN expression on podocytes and its role in inflammatory immune response of lupus nephritis

• DOI: 10.1111/cei.12723
• Publication Date: 2015-10-06T23:14:41Z
• Authors: Minchao Cai; Tong Zhou; Xuan Wang; Minghua Shang; Yueyue Zhang; Maocai Luo; Chundi Xu; Weijie Yuan
• Keywords: DC-SIGN; Nephrin; Nephritis

Summary Podocytes, the main target of immune complex, participate actively in development glomerular injury as cells. Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate molecular that has recognition function, and involved mediation cell immunoregulation. Here we explored expression DC-SIGN on podocytes its role inflammatory responses lupus nephritis (LN). Expression immunoglobulin (Ig)G1 was observed glomeruli LN patients. co-expressed with nephrin podocytes. Accompanied by increased proteinuria mice, IgG1 expressions were from 20 weeks, renal function deteriorated up to 24 weeks. Mice anti-DC-SIGN antibody showed reduced remission function. After stimulated serum mice vitro, DC-SIGN, major histocompatibility complex (MHC) class II CD80 up-regulated, stimulation T proliferation enhanced interferon (IFN)-γ/interleukin (IL)-4 ratio increased. However, treatment reversed these events. These results suggested can exert DC-like through their which may be tissues. blockage inhibit functions podocytes, have preventive therapeutic effects.