Adiponectin concentration data improve the estimation of atherosclerotic risk in normal and in overweight subjects

• DOI: 10.1111/cen.13540
• Publication Date: 2017-12-27T09:41:45Z
• Authors: Adriana Bertolami; José C. de Lima‐J...; Riobaldo M. Cintra; Luiz S. Carvalho; Carolina de C. Go...; Martha L. Sulzbach; Ana C.G.P. Petisco; José E.M. Barbosa; André A. Faludi; Jorge Plutzky; Marcelo C. Bertolami; Andrei C. Sposito
• Keywords: Adult; Male; Anthropometry; Atherosclerosis; Carotid Intima-Media Thickness; Risk Assessment; Body Mass Index; 3. Good health; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; Humans; Female; Adiponectin; Biomarkers

The combinations of adipokines and body mass parameters to estimate carotid atherosclerotic disease have not been completely delineated.To test the well-established, easily accessible indices circulating biomarkers identify increased intima-media thickness (cIMT) in a primary prevention setting.In cross-sectional analysis 339 asymptomatic individuals with no history cardiovascular events, inflammatory insulin sensitivity as well adipokine levels were measured combined evaluate best marker for cIMT.As isolated parameters, index (BMI) adiponectin identified abnormal cIMT (P = .04). Adiponectin also linked relationship between BMI (β 0.0371; P .01). Twenty-nine missed by alone but detected combining measurements. When compared alone, combination plus improved c-statistic (0.549-0.567) integrated discrimination improvement (0.01725; .021). Segregation use + is associated significant differences sensitivity, glomerular filtration rate, systemic activity, dyslipidaemia cIMT.Combining plasma measurements improves estimation anthropometric parameters.