Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study

• DOI: 10.1111/cen.15250
• Publication Date: 2025-04-11T05:52:02Z
• Authors: Harshal Deshmukh; Milly Newham; Emmanuel Ssemmondo; Elizabeth Pond; Punith Kempegowda; Majid Al‐Abbood; Usman Malabu; Thozhukat Sathyap...
• Keywords: General Health Questionnaire

ABSTRACT Introduction Polycystic ovary syndrome (PCOS) presents complex challenges during pregnancy, affecting both maternal and neonatal health. This study aims to provide a comprehensive analysis of the demographic, social clinical dimensions PCOS in utilising data from Born Bradford (BiB) cohort. Methods A retrospective cohort used BiB cohort, including pregnant women with control group. Demographic, social, characteristics were analysed, collected electronic health records, questionnaires, medical records. The General Health Questionnaire‐28 (GHQ‐28) assessed overall well‐being psychological distress. Statistical included descriptive statistics, Fischer's exact tests, independent t ‐tests, Mann–Whitney U logistic regression analysis. Results 279 diagnosed 10,284 controls. After adjusting for age, had significantly higher GHQ‐28 scores than controls ( β = 2.65, SD 0.86, p 0.002). was associated increased odds pre‐eclampsia (OR: 2.09, 95% CI: 1.18–3.71, 0.01) gestational hypertension 1.69, 1.19–2.38, 0.005). However, after BMI, association between no longer significant, though mediation confirmed that BMI played significant mediating role. Infants born mothers stillbirth 4.93, 1.92–12.62, 0.005) lower birth weights. gender‐stratified showed reduction weight particularly pronounced female infants (3164.5 ± 535.7 g vs. 3011.2 581.0 g; 0.004), whereas difference observed male > 0.05). Conclusion findings underscore importance considering factors management PCOS.