More than the heart: Hepatic, renal, and cardiac dysfunction in adult Fontan patients

• DOI: 10.1111/chd.12820
• Publication Date: 2019-07-08T06:19:35Z
• Authors: Ryan D. Byrne; Angela J. Weingarten; Daniel E. Clark; Shi Huang; Roman E. Perri; Andrew E. Scanga; Jonathan N. Menachem; Larry W. Markham; Benjamin P. Frisc...
• Keywords: Cardiac catheterization

Fontan-associated liver disease universally affects adults with single ventricle heart disease. Chronic kidney is also highly prevalent in adult Fontan patients. In this study, we evaluate the relationship of hemodynamics invasively and noninvasively extra-cardiac dysfunction as measured by MELD MELD-XI.We hypothesize that invasive noninvasive measures circuit congestion ventricular are associated increased MELD-XI scores.Single-center data from palliation who had ongoing care, including cardiac catheterization, were retrospectively collected. Hemodynamic catheterization echocardiographic assessment atrioventricular valve function tested for association serum creatinine, MELD, MELD-XI. Linear regression was used to perform multivariable analysis echocardiogram cohort.Fifty-seven patients congruent lab analysis. Sixty-three sixty-nine MELD-XI, respectively. Of hemodynamic variables analyzed, only decreased systemic oxygen saturation significant correlation elevated (P = .045). Patients moderately or severely reduced ejection fraction significantly higher scores compared those normal mildly depressed systolic .008 P < .001 respectively). Significant differences creatinine found among groups .02).In following palliation, hepatic renal assessed scores.