Ectopic bone formation in and soft‐tissue response toP(CL/DLLA)/bioactive glass composite scaffolds

• DOI: 10.1111/clr.12051
• Publication Date: 2012-10-29T19:49:26Z
• Authors: Ville V. Meretoja; Teemu Tirri; Minna Malin; Jukka V. Seppälä; Timo O. Närhi
• Keywords: Bioactive Glass; Bone tissue

Abstract Objectives To characterize biological response to subcutaneously implanted macroporous poly(ε‐caprolactone/D,L‐lactide)‐based scaffolds, and evaluate the effect of bioactive glass ( BAG ) filler osteogenic cells tissue ectopic bone formation. Material methods In first part this study, six different scaffold types were screened in a rat subcutaneous implantation model. The polymer scaffolds with 70/30 caprolactone/lactide ratio corresponding composites < 45 μm size chosen for further formation assay. loaded differentiating marrow stromal syngeneic rats. Results With plain only mild foreign body reaction no signs gross inflammation was observed after 4 weeks implantation. Furthermore, fully invaded by well‐vascularized soft connective tissue. Overall, all tested showed an appropriate host response. cell‐seeded several loci immature mineralizing small amounts mature weeks. incidence two four composites, respectively n = 8). After twelve weeks, one but seven Excluding formation, considered similar that cell‐free scaffolds. Conclusions Plain supported ingrowth fibroconnective cell seeded enhanced comparison neat