Reconstructive surgical therapy of peri‐implantitis: A multicenter randomized controlled clinical trial

• DOI: 10.1111/clr.13972
• Publication Date: 2022-07-09T04:48:28Z
• Authors: Jan Derks; Alberto Ortiz‐Vigón; Adrián Guerrero; Mauro Donati; Eriberto Bressan; Paolo Ghensi; Dennis Schaller; Cristiano Tomasi; Karolina Karlsson; Ingemar Abrahamsson; Yuki Ichioka; Carlotta Dionigi; Erik Regidor; Tord Berglundh
• Keywords: Peri-implantitis

To evaluate the potential benefit of use a bone substitute material in reconstructive surgical therapy peri-implantitis.In this multicenter randomized clinical trial, 138 patients (147 implants) with peri-implantitis were treated surgically, by coin toss to either control (access flap surgery) or test group (reconstructive surgery using material). Clinical assessments, including probing pocket depth (PPD), bleeding and suppuration on (BOP & SOP) as well soft tissue recession (REC), recorded at baseline, 6 12 months. Marginal levels (MBL), measured intra-oral radiographs, patient-reported outcomes (PROs) baseline No blinding allocation was performed. The primary outcome months composite measure (i) implant not lost, (ii) absence BOP/SOP all aspects, (iii) PPD ≤5 mm aspects (iv) ≤1 mucosal margin buccal aspect implant. Secondary included changes MBL, PPD, BOP%, KM, REC outcomes.During follow-up, four implants (one group, three group) removed due disease progression. At months, total 69 68 examined. Thus, 16.4% 13.5% respectively, met predefined criteria outcome. reduction MBL gain 3.7 about 1.0 both groups. Reduction mean BOP% varied between 45% (test) 50% (control), without significant differences Buccal less pronounced (M = 0.7, SD 0.9 mm) when compared controls 1.1, 1.5 mm). PROs favorable groups differences. One case allergic reaction antibiotic recorded. other adverse events noted.Surgical effectively improved radiographic status While did improve reductions BOP, group. Patient satisfaction high