Adaptive immunity is essential in preventing recrudescence ofPlasmodium yoeliimalaria parasites after artesunate treatment

• DOI: 10.1111/cmi.12763
• Publication Date: 2017-06-30T05:06:44Z
• Authors: Carla Claser; Zi Wei Chang; Bruce Russell; Laurent Rénia
• Keywords: Plasmodium yoelii; Artesunate; Plasmodium (life cycle)

Artemisinin-based antimalarials, such as artesunate (ART), alone or in combination, are the mainstay of therapy against malaria caused by Plasmodium falciparum. However, emergence and spread artemisinin resistance threatens future success its global eradication. Although much reported can be attributed to mutations intrinsic parasite, a significant proportion treatment failures thought due other factors host's immune system. Exactly how system participates clearance elimination parasites during ART is unknown. Here, we show that developing primary response, involving both B CD4+ T cells, necessary for complete but not initial clearance, yoelii YM mice treated with ART. Our study uncovers dynamic interplay between host adaptive immunity sp. elimination.