A coiled-coil protein is required for coordination of karyokinesis and cytokinesis in Toxoplasma gondii

• DOI: 10.1111/cmi.12832
• Publication Date: 2018-02-15T18:22:41Z
• Authors: Flavie Courjol; Mathieu Gissot
• Keywords: Schizogony; Centrosome cycle

Toxoplasma gondii is a unicellular eukaryotic pathogen that belongs to the Apicomplexa phylum, which encompasses some of deadliest pathogens medical and veterinary importance. The centrosome key organisation coordination cell cycle division apicomplexan parasites. T. possesses particular bipartite structure (outer inner cores). One main roles ensure proper karyokinesis. However, how these 2 events are coordinated still unknown in gondii, for components poorly described. To gain more insights into biology composition centrosome, we characterised protein resides at interface outer core centrosomes. TgCep530 large coiled-coil with an essential role survival parasite. Depletion this leads accumulation parasites lacking nuclei disruption normal cycle. Lack results discoordination between nuclear budding yields fully formed without nuclei. has crucial karyokinesis cytokinesis.