Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease

• DOI: 10.1111/cns.13914
• Publication Date: 2022-07-13T11:44:42Z
• Authors: Jovana Aranđelović; Anja Santrač; Bojan Batinić; Lidija Todorović; Vladimir Stevanović; Veera Venkata Nag...; Dishary Sharmin; Farjana Rashid; Boban Stanojević; James M. Cook; Miroslav M. Savić
• Keywords: cognition; Male; 570; Social Interaction; Mice, Transgenic; neuroinflammation; Mice; 03 medical and health sciences; Alzheimer Disease; Memory; 616; Animals; gamma-Aminobutyric Acid; 0303 health sciences; Amyloid beta-Peptides; Interleukin-6; Tumor Necrosis Factor-alpha; Original Articles; Alzheimer's disease; Receptors, GABA-A; 5xFAD; α5 GABAA receptor modulation; 3. Good health; Disease Models, Animal; Neuroinflammatory Diseases; Solvents; Female

GABAergic modulation involved in cognitive processing appears to be substantially changed Alzheimer's disease (AD). In a widely used 5xFAD model of AD, we aimed assess if negative and positive allosteric modulators α5 GABA