White matter integrity mediates the associations between white matter hyperintensities and cognitive function in patients with silent cerebrovascular diseases

• DOI: 10.1111/cns.14015
• Publication Date: 2022-11-23T06:52:47Z
• Authors: Jing Chen; Anyan Ge; Ying Zhou; Yuanyuan Ma; Shaoping Zhong; Caizhong Chen; Weibin Shi; Jing Ding; Xin Wang
• Keywords: Superior longitudinal fasciculus; Fasciculus; Uncinate fasciculus

Abstract Objective To evaluate the relationships between cognitive function and white matter hyperintensity volume (WMHV) in patients with silent cerebrovascular disease to investigate whether integrity or brain atrophy play a role this association. Methods Automated Fiber Quantification Voxel‐ based morphometry were used track identify of 20 well‐defined tracts measure gray (GMV). A linear regression model was applied for examining associations WMHV mediation analysis roles GMV influence on function. Results Two hundred thirty‐six individuals included analysis. Executive linearly associated fractional anisotropy (FA) right interior frontal occipital fasciculus (IFOF) ( β = 0.193; 95% CI, 0.126 1.218) −0.188; −0.372 −0.037). Information processing speed −0.357; −0.643 −0.245), FA anterior thalamic radiation (ATR) 0.207; 0.116 0.920), left superior longitudinal (SLF) 0.177; 0.103 1.315). The relationship executive mediated by IFOF (effect size −0.045, −0.015 −0.092). Parallel showed that association information ATR −0.099, −0.198 −0.038) SLF −0.038, −0.080 −0.003). Conclusion These findings suggest mechanism which WMH affects impairing integrity. This may be helpful providing theoretical basis rehabilitation strategies diseases.