Association of serum uric acid to lymphocyte ratio, a novel inflammatory biomarker, with risk of stroke: A prospective cohort study

• DOI: 10.1111/cns.14094
• Publication Date: 2023-01-18T07:25:15Z
• Authors: Xue Tian; Penglian Wang; Shuohua Chen; Yijun Zhang; Xiaoli Zhang; Qin Xu; Yanxia Luo; Shouling Wu; Anxin Wang
• Keywords: Stroke

Inflammation plays an important role in the pathological progress associated with stroke. Serum uric acid (SUA) to lymphocyte ratio (ULR), a novel inflammatory biomarker, has been considered as better risk stratification tool of adverse outcomes than SUA or alone. This study aimed investigate whether ULR produced more predictive value for stroke and explore potential mediators associations.This enrolled 93,023 Chinese participants without myocardial infarction at baseline. Cox proportional hazard models were used analyze associations subtypes. Mediation analyses conducted associations.During median follow-up 13.00 years, 6081 cases incident occurred, including 5048 ischemic (IS) 900 hemorrhagic (HS). After adjustment confounders, Q4 group was higher HS (HR, 1.25; 95% CI, 1.03-1.50), but not total 1.07; 1.03-1.13) IS 1.04; 0.97-1.12). No significant found between any outperformed lymphocytes alone predicting Additionally, association partially mediated by systolic blood pressure (20.32%), diastolic (11.18%) estimated glomerular filtration rate (9.19%).ULR significantly HS, IS. Systolic pressure, association.