Advancing stroke therapy: A deep dive into early phase of ischemic stroke and recanalization

• DOI: 10.1111/cns.14634
• Publication Date: 2024-02-21T03:47:12Z
• Authors: Qianyan He; Yueqing Wang; Cheng Fang; Ziying Feng; Meifang Yin; Juyang Huang; Yinzhong Ma; Zhizhun Mo
• Keywords: Stroke

Ischemic stroke, accounting for the majority of stroke events, significantly contributes to global morbidity and mortality. Vascular recanalization therapies, namely intravenous thrombolysis mechanical thrombectomy, have emerged as critical interventions, yet their success hinges on timely application patient-specific factors. This review focuses early phase pathophysiological mechanisms ischemic nuances recanalization. It highlights dual role neutrophils in tissue damage repair, involvement blood-brain barrier (BBB) outcomes. Special emphasis is placed ischemia-reperfusion injury, characterized by oxidative stress, inflammation, endothelial dysfunction, which paradoxically exacerbates cerebral post-revascularization. The also explores potential targeting molecular pathways involved BBB integrity inflammation enhance efficacy therapies. By synthesizing current research, this paper aims provide insights into optimizing treatment protocols developing adjuvant neuroprotective strategies, thereby advancing therapy improving patient