Specific barrier response profiles after experimentally induced skin irritation in vivo

• DOI: 10.1111/cod.12981
• Publication Date: 2018-04-02T08:16:46Z
• Authors: Maryam Soltanipoor; Tasja Stilla; Christoph Riethmü...; Jacob P. Thyssen; Judith K. Sluiter; Thomas Rustemeyer; Tobias W. Fischer; Sanja Kezic; Irena Angelova‐Fi...
• Keywords: Transepidermal water loss; Erythema; Irritant contact dermatitis; Barrier function; Volunteer

Background Recently, natural moisturizing factors (NMFs) and corneocyte surface topography were suggested as biomarkers for irritant dermatitis. Objectives To investigate how exposure to different irritants influences topography, NMF levels the barrier function of human skin in vivo. Methods Eight healthy adult volunteers exposed aqueous solutions 60% n‐propanol, 0.5% sodium lauryl sulfate (SLS), 0.15% hydroxide, 2.0% acetic acid, distilled water, a repeated irritation test over period 96 hours. Erythema, transepidermal water loss (TEWL), hydration, dermal texture index (DTI) measured at baseline, after 24 Results SLS hydroxide had most pronounced effects on erythema TEWL. Although n‐propanol caused only slight changes TEWL erythema, it showed levels, DTI. was parameter that significantly altered by all investigated irritants. The DTI inversely associated with hydration. Conclusion Skin impairment inflammatory response are irritant‐specific, emphasizing need multiparametric approach study irritation. seem be sensitive detecting irritant‐induced alterations.