Prognostic and diagnostic significance of annexin A2 in colorectal cancer

• DOI: 10.1111/codi.12207
• Publication Date: 2013-03-14T02:53:41Z
• Authors: T. Yang; H. Peng; J. Wang; J. Yang; E. C. Nice; K. Xie; C. Huang
• Keywords: Adult; Aged, 80 and over; Male; Kaplan-Meier Estimate; Middle Aged; Prognosis; Immunohistochemistry; Sensitivity and Specificity; Disease-Free Survival; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; ROC Curve; Biomarkers, Tumor; Linear Models; Humans; Female; Neoplasm Recurrence, Local; Colorectal Neoplasms; Annexin A2; Aged; Proportional Hazards Models

Annexin A2 (ANXA2) is known to be a tumourigenic molecule and highly expressed in colorectal cancer (CRC). Its diagnostic prognostic value not fully understood. This study was designed investigate the relationship between ANXA2 expression, clinicopathological characteristics, tumour recurrence survival.Immunohistochemical staining used evaluate expression 150 matched samples from patients with CRC. Overall survival were determined by Kaplan-Meier analysis. The Cox proportional hazards model determine independent factors contributing recurrence. Receiver operating characteristic (ROC) curve liner correlation analysis estimate sensitivity specificity of for clinical diagnosis.ANXA2 found strongly poorly differentiated tumours (P < 0.001), late stage = 0.020) lymph node positivity 0.002). significantly related 0.001) indicated that [P 0.001, hazard ratio (HR) 1.366, 95% CI 1.232-1.515] location 0.039, HR 1.891, 1.034-3.456) predicting overall while 1.445, 1.222-1.709) (AUC 0.768, 0.642-0.894) suggested suitable diagnosis CRC.These results indicate biomarker potential