The Aortic Calcification Index is a risk factor associated with anastomotic leakage after anterior resection of rectal cancer

• DOI: 10.1111/codi.14795
• Publication Date: 2019-07-30T14:58:34Z
• Authors: Z. Shen; Y. An; Y. Shi; M. Yin; Q. Xie; Z. Gao; K. Jiang; S. Wang; Y. Ye
• Keywords: Male; Proctectomy; Rectal Neoplasms; Aortic Diseases; Anastomotic Leak; Middle Aged; Atherosclerosis; Prognosis; Severity of Illness Index; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Risk Factors; Humans; Female; Aged; Retrospective Studies

Abstract Aim Anastomotic leakage ( AL ) is one of the most feared postoperative complications after anterior resection (AR) rectal cancer. An adequate blood supply at anastomotic site regarded as a prerequisite for healing. We hypothesize that Aortic Calcification Index ACI might reflect severity atherosclerosis in patients, and thereby be risk factor . Method was investigated retrospectively according to definition International Study Group Rectal Cancer 423 cancer patients who underwent resection. The measured by preoperative abdominal CT scan. cross‐section aorta evenly divided into 12 sectors, number calcified sectors counted calcification score each slice. Lasso logistic regression multivariate analysis were used identify factors Results percentage AR 7.8% (33/423); mortality sustained leak 3.0% (1/33). Patients with high had significantly higher than low (11.2% vs 5.6%, P = 0.04). Among , associated greater (the grade A leakage, B C 0.5% ± 0.2%, 11.5% 9.2% 24.2% 21.7%, respectively; 0.008). After adjustment, showed an independent OR 2.391, Conclusion important prognostic Confirmatory studies are required.