MUTYH‐associated polyposis – colorectal phenotype and management

• DOI: 10.1111/codi.15078
• Publication Date: 2020-04-20T05:25:34Z
• Authors: R. Patel; P. McGinty; V. Cuthill; M. Hawkins; M. Moorghen; S. K. Clark; A. Latchford
• Keywords: MUTYH

Abstract Aim The aim was to determine the presentation, management and outcomes of MUTYH ‐associated polyposis (MAP). Method A prospectively maintained database used identify patients with MAP. Demographic data on germline mutation, surgical management, histopathology tumours endoscopic surveillance were collected. Results In all, 134 MAP identified. majority presented symptomatically ( n = 83). Sixty‐eight developed cancer (seven synchronous, 12 metachronous). median age at diagnosis first colorectal 47 years (range 33–74 years). Cancers occurred in context a few adenomas (< 10). 108) had surgery as line management. One patient received palliative care. Twenty‐five management; no cancers this group. Patients who segmental resection postoperative still appeared be risk metachronous (5/30, 17%). Conclusions testing should considered even occurring fewer than 10 adenomas. cases primary cancers, extended if do not have access high quality postoperatively. For some patients, therapy is an appropriate safe option expert hands.